Thomas F. Boyd served as president of William Penn College/William Penn University from 1998 to 2003. In 2000 he changed the name of the institution from William Penn College to William Penn University.
O. Duane Moon served as president of William Penn College from 1964 to 1979. He enjoyed his tenure as president, even when students where in his office demanding to be allowed to smoke in the newly open Student Union.
John A. Fallon served as president of William Penn College from 1995 to 1998. During his tenure in office the College launched the College for Working Adults (CWA) program.
John D. Wagoner served as president of his alma mater William Penn College from 1984 to 1995. President Wagoner started the Advancement Office at William Penn College in 1964 and served as head until 1984 when he assumed the presidency.
Gus Turbeville was the president of William Penn College from 1979 to 1984. He implemented on of the most unique curricular changes in the College's history, the Great Issues Program.
S. Arthur Watson served as president of William Penn College from 1958 to 1964. He was instrumental in regaining accreditation for the college in 1960. He was trained as a biologist and was a nature enthusiast.
Charles S. Ball served as president of William Penn College from 1949-1958. He had an advanced degree in theology and was the former president of Friends Bible College in Haviland, Kansas.
Dr. Benjamin F. Andrews was a Penn College graduate and a medical doctor. He served on the Board of Trustees from 1917 to 1952. Dr. Andrews served as acting president of William Penn College for the academic year 1934-1935.