Cecil E. Hinshaw was president of William Penn College from 1944 to 1949. His administration would be one of the times when Quaker values were voiced and acted upon. His time at Penn is called, "The Holy Experiment".
Dr. Benjamin F. Andrews was a Penn College graduate and a medical doctor. He served on the Board of Trustees from 1917 to 1952. Dr. Andrews served as acting president of William Penn College for the academic year 1934-1935.
S. Arthur Watson served as president of William Penn College from 1958 to 1964. He was instrumental in regaining accreditation for the college in 1960. He was trained as a biologist and was a nature enthusiast.
John D. Wagoner served as president of his alma mater William Penn College from 1984 to 1995. President Wagoner started the Advancement Office at William Penn College in 1964 and served as head until 1984 when he assumed the presidency.